5-HT Receptor Agonist

5-HT Receptor Agonists (62):

Cat. No.	Product Name	Effect	Purity

HY-B0670A

Dihydroergotamine mesylate	Agonist	99.94%
Dihydroergotamine mesylate is an ergot alkaloid that can be used for the research of migraines.

HY-B1473AS

Serotonin-d₄	Agonist	99.60%
Serotonin-d₄ is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.

HY-102064

SR 57227A	Agonist	99.86%
SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC₅₀) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects.

HY-W028142

Quipazine	Agonist
Quipazine is a 5-HT agonist with a K_i value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine shows antiviral activity against SARS-CoV-2 with an EC₅₀ of 31.64 μM. Quipazine behaves as a 5-HT3R agonist in peripheral models. Quipazine can be used for neurological disease research.

HY-109157

Ralmitaront	Agonist	99.92%
Ralmitaront (RO6889450) is an orally active agonist of trace amine-associated receptor 1 (TAAR1) with a EC₅₀ value of 110.4 nM. Ralmitaront has antipsychotic, cognitively improvement, and antidepressant activity in rodents. Ralmitaront can be used as a neurosuppressant in the study of neuro-related diseases, such as schizophrenia (SCZ), schizoaffective disorder.

HY-161246

uPSEM792	Agonist	99.92%
uPSEM792 is a pharmacologically selective effector molecules (PSEM) agonist for PSAM⁴-GlyR, with an affinity of K_i of 0.7 nM. uPSEM792 is a substrate for efflux transporters in brains of wild type and dual P-gp and BCRP knockout mice. uPSEM7952 is a possible lead for developing the PET radioligand for PSAM⁴-GlyR.

HY-B1473S

Serotonin-d₄ hydrochloride	Agonist	98.58%
Serotonin-d₄ (5-Hydroxytryptamine-d₄) hydrochloride is the deuterium labeled Serotonin (hydrochloride) (HY-B1473). Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM.

HY-124501

LY 165163	Agonist	99.24%
LY 165163 is a potent 5-HT presynaptic receptor agonist. LY 165163 significantly decreases 5-HTP accumulation and increases DOPA accumulation in the cortex and striatum.

HY-145463

α-Methylserotonin	Agonist
α-Methylserotonin is a potent and selective agonist of 5-HT₂ receptor. α-Methylserotonin is an analogue of serotonin formed in vivo from α-methyltryptophan. α-Methylserotonin mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis.

HY-14441

ML 10302	Agonist	98.95%
ML 10302 is a potent agonist 5-HT4 receptor with K_i of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases.

HY-14151S

Prucalopride-¹³C,d₃	Agonist	≥99.0%
Prucalopride-¹³C,d₃ is the ¹³C- and deuterium labeled Prucalopride.

HY-136109B

(Rac)-SEP-363856	Agonist
(Rac)-SEP-363856 is the racemate of SEP-363856. SEP-363856（SEP-856）, an orally active and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 （SEP-856） has the potential for the treatment of schizophrenia.

HY-B0189S1

Mosapride-d₅	Agonist
Mosapride-d₅ is the deuterium labeled Mosapride. Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.

HY-B1115S

Buspirone-d₈ hydrochloride	Agonist
Buspirone-d₈ (hydrochloride) is the deuterium labeled Buspirone hydrochloride. Buspirone hydrochloride is an anxiolytic psychotropic agent, is used to treat generalized anxiety disorder (GAD).

HY-155116

5-HT6 agonist 1	Agonist
5-HT6 agonist 1 (Compound 19) is a 5-HT6 agonist (K_i: 5 nM). 5-HT6 agonist 1 has antidepressant-like properties, and improves cognitive deficits. 5-HT6 agonist 1 also inhibits platelet aggregation. 5-HT6 agonist 1 has high metabolic stability.

HY-117090

(rac)-AL-37350A	Agonist
(rac)-AL-37350A ((rac)-4,5-DHP-AMT) is a 5-HT2 receptor agonist with intraocular pressure-lowering activity. (rac)-AL-37350A has high affinity and selectivity for the 5-HT2 receptor and effectively reduces intraocular pressure in conscious hypertensive cynomolgus monkeys.

HY-101342

RS 67506 hydrochloride	Agonist
RS 67506 hydrochloride is a 5-HT4 receptor agonist. The pKi value of RS 67506 hydrochloride for 5-HT4 in guinea pig striatum is 8.8. RS 67506 hydrochloride can be used in neuro-related research.

HY-172978

5-HT2A receptor agonist-8	Agonist
5-HT2A receptor agonist-8 (compound 8) is a potent 5-HT2A receptor agonist with an EC₅₀ of 0.6784nM. 5-HT2A receptor agonist-8 can be used in the study of depressive disorders and bipolar disorders.

HY-118008

Lesopitron	Agonist
Lesopitron (E-4424) is a 5-HT receptor agonist with potent anxiolytic-like effects. Lesopitron inhibits forskolin-stimulated adenylate cyclase activity with an IC₅₀ value of 125 nM.

HY-167687

(RS)-Minesapride	Agonist
(RS)-Minesapride is a serotonin receptor agonist, exhibiting potential therapeutic activity for patients with irritable bowel syndrome with predominant constipation (IBS-C).

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